Since there are many strengths of conjugated estrogens and medroxyprogesterone available, ask your provider which combination strength you should be taking. You should not use Prempro if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will be having major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina. a clot in the small veins that carry blood to or from the retina of the eye. Please stop using it ! Like. I think taking it the same time everyday has helped with that. Hot flashes were about to finish me off. - this has improved some, but not happy with the mood swings and spotting. ", "Periods recommenced on using this, also got menstrual cramps (which I had before so no huge deal). Not sore so much as tender So I tried in the morning. Take the medicine at the same time each day. The only objection I have is the urine from horses. ", "I have been on this medication for 37 days. The hormone therapy can increase your risk of certain health conditions, such as breast cancer and heart disease. Within two weeks, I felt so much bette. I'm so confused and don't know what to do. side effects. Hot flashes are almost none, started my period this month after not having one in almost a yearbummer! My mood has not changed, I'm still moody. information and will only use or disclose that information as set forth in our notice of And I really do not want that weight gain. Available for Android and iOS devices. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Any advice from anyone I would appreciate it. I am so much less moody, have more motivation and way less hungry. Follow all directions on your prescription label. When the endometrium is no longer shed, estrogen can cause an overgrowth of cells in your uterus, a condition that can lead to cancer. Also, not as hungry as normal. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. My day and night sweats are no longer severe. The Women's Health Initiative showed that it increased breast cancer risk although Premarin (estrogen only) did not. I was bleeding almost every day. After two months, I still had a headache and was weeping into my lunch. All of the docs and insurance kept trying to push anti-anxiety meds. I feel bloated and tired. User Reviews for Prempro to treat Postmenopausal Symptoms. My hormones were out of whack. At about the 5 year mark, my doctor strongly encouraged that I wean off Prempro, informing me that my chances of breast cancer and/or stroke increases after 5 years. Copyright 2023 IBM Watson Health. My mood swings are gone, I am back to normal. ", "I was prescribed Prempro 6 years ago at age 53.5 and it proved to be very beneficial. I'm 57 now and I plan on taking this low dose for the rest of my life. I started out at a full dose and quickly realized it was way too much. Author disclosure: No relevant financial affiliations. Find out the best time to take vitamins to increase their benefits, including the best time to take vitamins D, B12 and C, multivitamins and prenatal vitamins. Also want to mention that since menopause, I have zero Interest in sexual relations with my husband. I've been taking the lowest dosage of Prempro for approximately six months and it has worked well to say the least. To help relieve this pain, antacids may be taken with omeprazole, unless your doctor tells you otherwise. No more! Adults20 or 40 milligrams (mg) one, two, or three times a day before a meal. The applesauce should not be hot and should be soft enough to be swallowed without chewing. I was back to the hormone level of an 11 year old. Empty packet of powder into a small cup containing 2 tablespoons of water. Children 1 year of age and olderDose is based on body weight and must be determined by your doctor. The only symptoms I have had are tenderness in the breast area. This medicine should come with a Medication Guide. HRT works for me and I'll probably have to take it until I die. a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina. Taking vitamins can be a great way to support your nutritional needs but there is a right way to do it. Other Dr's have said don't do that. I'm 57 now and I plan on taking this low dose for the rest of my life. I have no history of breast cancer in my family, it's cant really rate because I only took for about 1 week seemed to help some, but am a 53 yr old smoker who likes to lay in sun. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. She reluctantly did it.. but didn't think that it would do any good. We comply with the HONcode standard for trustworthy health information. Grapefruit and grapefruit juice may interact with conjugated estrogens and medroxyprogesterone and lead to unwanted side effects. All rights reserved. The Best IOL for 2022 RXSight Light Adjusted Lens, Will refractive surgery such as LASIK keep me out of glasses all my life. Dr. Perez-Gallardo says its less about time of day and more about syncing the habit with your eating and drinking schedule. Now my heat flashes, night sweats and weight gain has stopped! a migraine headache. I shared this with my doctor and she suggested I get back on Prempro. Using this medicine can increase your risk of blood clots, stroke, or heart attack. WebMD does not provide medical advice, diagnosis or treatment. The only side effect Ive experienced in the negative is my breasts are a bit more tender than norm. Copyright Family Physicians Inquiries Network. In two studies, levothyroxine taken at least two hours after eating in the evening maintained or improved TSH levels compared with morning administration. Prozac (fluoxetine) is generally recommended to be taken in the morning, but can safely be taken at any time during the day. Patients received each regimen for three months, and reported not eating for several hours before bedtime administration. I started at the age of 57 and it did help with some of my problems. old. There are other ways to restore healthy sleep. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (https://www.cebm.net). It saved my life. I hit the jackpot! The drop in hormone levels at the end of the day actually signals the body that it needs to make another batch of hormones. Follow your doctor's orders or the directions on the label. Hopefully that will continue. I watch everything I eat and workout at least 5, days a week, so this is disheartening. I quit taking it and the yeast infections never came back but left me. The first study on this drug was totally flawed I started out at a full dose and quickly realized it was way too much. I used to have to strip down and sit in front of a fan just to enjoy a cup of coffee. Members of the network select questions based on their relevance to family medicine. I have been on Prempro (lowest dose available) for 10 years and love it!! Mayo Clinic does not endorse companies or products. Standard dosage: 0.625 conjugated estrogen/2.5 mg MPA (daily with Prempro; with Premphase, you take the progestin only 2 weeks out of the month). The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. No hot flashes. A 2015 randomized, double-blind, placebo-controlled, crossover study compared the effects of morning (30 minutes before breakfast) vs. evening (60 minutes before dinner) administration of levothyroxine in 50 adults with hypothyroidism.3 A therapeutic TSH level was required for inclusion. My mood actually seems to have improved but who knows this year has been crazy for all. F: 53 15 years.625 1X D . These side-effects became unbearable so I had my doctor switch me to. She reluctantly prescribed another year. Hopefully it gets better. The dose is usually 5 to 20 mg once a day before a meal. No hot flashes and sleeping much better at night, Now that I am at 3 months of medication, I am more tired and now have weight gain! I have noticed caffeine and stress brings on the flashes. I was actually able to sleep my full time without waking up!!! Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox. ", "I have been on Prempro for 6 years until recently I developed lymphadenopathy a breast cancer in lymph and glands with no primary source in my breast or body. Your doctor may want you to take omeprazole for more than 8 weeks for certain conditions. I have noticed a huge difference in dryness in a vagina which is awesome. I asked to please stay on Prempro as I believe my quality of life is far more important than the slight risks associated with extended use. Cleveland Clinic 1995-2023. I had one pregnancy. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. I started this medication about a week ago, and have not had any issues with it yet, but I have not had any relief with my hot flashes yet and was just curious what others thought. Any doctor or surgeon who treats you should know that you are using Prempro. Hope it keeps working. has an average rating of 7.2 out of 10 from a total of 45 reviews Selected from data included with permission and copyrighted by First Databank, Inc. And yes, some women are given progesterone at night to help them sleep. Create an account with us and you'll be able to: Fill in your email below to request a new password. Ask your healthcare professional how you should dispose of any medicine you do not use. I had hot flashes but moderately. Get Your Nutrients From Food, Not Supplements, 6 Sore Throat Remedies That Actually Work. I also had a hereditary gene study done and it was negative. Keep from freezing. Ask your doctor or pharmacist if you have any questions. Report any unusual vaginal bleeding right away. Vitamin C and vitamin B12 are water-soluble vitamins, which means you need water to absorb them. I have been off since this finding as hormone replacement will feed cancer. 2005 - 2023 WebMD LLC. I found it helpful for prevention of hot flashes initially, and now helpful for vaginal dryness and overall dryness. ", "I was feeling stuck in perpetual PMS. Shake the syringe and give the medicine through the nasogastric or gastric tube into the stomach with 30 minutes. information highlighted below and resubmit the form. It's been several years since I quit taking Prempro due to constant yeast infections of which the Dr. didn't believe me. will you or will you only have 1 more year of symptoms, thats what no one seems to know for sure. I would wake up at night and couldn't go back to sleep - no matter how hard I tried. I used to have to strip down and sit in front of a fan just to enjoy a cup of coffee. Avoid smoking. ", "I was prescribed .625 Prempro at the age of 38. Prempro is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Has anyone tried Flax for menopausal symptoms? Refill the syringe with an equal amount of water. What a wonderful little pill!!! Medication compliance was not reported. Do not take this medicine in larger amounts or for longer than recommended. Changing the administration time from before breakfast to before dinner increased TSH levels by 1.47 mIU per L (P = .001). Also . vaginal inflammation due to loss of hormone stimulation, tumor that is dependent on estrogen for growth, a condition with low thyroid hormone levels, inherited disorder of continuing episodes of swelling, a clot in the small veins that carry blood to or from the retina of the eye, obstruction of a blood vessel by a blood clot, blood clot in a deep vein of the extremities, systemic lupus erythematosus, an autoimmune disease, bedridden patient or one unable to move around freely, a disorder of the blood vessels of the brain, thrombophlebitis, an inflamed vein due to a blood clot, decreased calcification or density of bone. Tell your doctor about all your current medicines and any medicine you start or stop using. Tonight will be my 4th dose and I honestly cannot wait to see how I feel after a week. To treat gastroesophageal reflux disease (GERD) for erosive esophagitis. Restful Sleep! I quit taking it and the yeast infections never came back but left me in a condition where I could no longer have sex with my husband due to severe raw pain. This content is owned by the AAFP. Saving the best for last, it restores the vagina from the ravaging effects of menopausal changes such as dryness and pain during sex. It's now $162. All patients received each levothyroxine regimen for eight weeks. The only thing left is this caused my cancer and a very very bad surgery please ladies dont take this medication . Portions of this document last updated: Feb. 01, 2023. I believe they could make a synthetic with the same properties of horse urine but apparently they don't care or don't want to spend the money.Read More Read Less. This medicine should come with a patient information leaflet. Decrease your dosage of Prempro. Brand names: Premphase, Prempro So for full absorption, Dr. Perez-Gallardo recommends taking water- and fat-soluble vitamins separately. Using Prempro can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. I plan to stop medication. A 2015 randomized, double-blind, placebo-controlled, crossover study compared the effects of morning (30 minutes before breakfast) vs. evening (60 minutes before dinner) administration of . All Rights Reserved. in terms of scientific protocol. I currently refer to my daily dose as "The Wonder Drug.". I have only been on this medication 48 hours and I am a different person already Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Read More Read Less, Took about three weeks for me to notice any benefits: hot flashes were nearly gone, brain fog was lifting, mood was improving. Without insurance, it would cost well over $200.00. This includes prescription and over-the-counter medicines, vitamins, and herbal products. The second was much more positive and so no increase in cancer but couldn't determine whether it helped prevent heart attacks. Only wanted to go on this for vaginal dryness and painful intercourse. You may report side effects to FDA at 1-800-FDA-1088. Estrogen lowers the hormone needed to produce breast milk and can slow breast milk production. Those meds have many side effects and the risk of suicide is much higher than the risk of breast cancer with Prempro. If interested in submitting questions or writing answers for this series, go to https://www.fpin.org or email: questions@fpin.org. I waved the white flag a month ago and asked my doctor to put me back on it. I was always scared of the risks involved. Within two weeks, I felt so much better. Take omeprazole capsules or delayed-release capsules before a meal, preferably in the morning. If you eat a nutritious, balanced diet, you do not need these supplements. After a full three months is when things went downhill: I had breast pain/swelling, fatigue, joint pain, and noticed that I had put 5 lbs on around my midsection (despite working out 6 days a week and not changing my diet). Mood swings are still there as well so Im hoping after 1 week I see a big change.. wish me luck", "I started Prempro in 2009, still taking it 9 years later at age 62. Do not keep outdated medicine or medicine no longer needed. Get emergency medical help if you have signs of an allergic reaction to Prempro: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Elevated evening estrogens interfere with growth hormone release. Cleveland Clinic is a non-profit academic medical center. - "And I looked prempro up and it has a cancer fighting drug in it too." The hot flashes are back just as bad as 8 years ago. If your dose is different, do not change it unless your doctor tells you to do so. I was told that I was too old for hot flashes. Asked my doctor about HRT and decided I wanted pill form. My day sweats are no longer embarrassing, e.g. After two months, I still had a headache and was weeping into my lunch. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Copyright 1996-2023 Cerner Multum, Inc. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. You can take your pill in the morning or at night. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The dose is usually 2.5 to 10 mg once a day before a meal. Low and behold I was in full on menopause. Adults40 milligrams (mg) once a day for 4 to 8 weeks. My doctor put me on Prempro. Children younger than 1 year of ageUse and dose must be determined by your doctor. I highly recommend this product, but the cost is way too high. After one month, my hot flashes were the worst they had ever been and I had a continuous headache. I sure hope to find something", "I'm 44 yrs old. I have been suffering with hot flashes for 16 years and I finally decided that I cannot do this anymore. But using progesterone this way is counter to the design of the body because progesterone is naturally higher in the morning. No more! I've saved and am going to read it later. Ten months ago I made the decision to wean off Prempro, and I can honestly say it was the worst decision. I started Prempro two weeks ago and I am officially hot flash free and happier then I have been in years! I liked the vitamins but I really love what Prempro gave me. Report any unusual vaginal bleeding right away. I broke down and purchased it to get relief. My sex drive is non-existent but I have a new, very strong, cuddle drive. I have depression but no antidepressant has ever worked for me. There is a problem with Prempro should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. Anyone try it or have a im a active, healthy 58 yr old woman. while talking with coworkers, I would without warning began to get warm, hot, and then dripping in sweat to include my hair. Has not increased my desire for sex either. You could also end up with an upset stomach. I cannot believe that it took me this many years to do this. What 11 year old wants sex? vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding. Before you start a daily vitamin habit, Dr. Perez-Gallardo emphasizes that not everyone needs them. I have new insurance, but my co-pay used to be $20.00. Prempro: Take 1 tablet by mouth once daily. Filter by condition. . and no matter what I do it wont budge. I did. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. I can't afford it at that price. About 1-2 months into treatment I was feeling better than I had in a long time. Im tornRead More Read Less, For more than a year, I tried black kohosh,soy isoflavones, evening primrose, sex essentials, hot plants and wild yam cream to no avail. Some doctors still try to move you to a vegetable supplement which does not work!! Insurance won't pay but Pfizer has approved me for free meds. The hormone replacement therapy's effects should be the same regardless of when it is taken. I began taking Prempro about 20 years ago and decided to quit and just suffer from the heat about a year and a half ago. So The million dollar question is will the symptoms start where they left off and run for five years? Taking estrogen without progesterone increases your risk for cancer of the endometrium (the lining of the uterus). This doctor was so adamant on me going back on the Prempro even when I told her nurse I wanted an alternativefor the hot flashes and did not want to continue the Prempro. As 4 the severe side effects go through most drugs u take and u will see the same ones. I am 50 now and my doctor would like to start weaning me off to since I've been on it for so long. Weakness, tiredness, shortness of breathe are common signs of Prempro and can also be an indication it maybe damaging your heart. Answers are drawn from an approved set of evidence-based resources and undergo peer review. hydrochlorothiazide, alendronate, estradiol, Fosamax, Prolia, calcium carbonate, Premarin, Estrace, Tymlos, Yuvafem. D and calcium. I appreciate how well this prescription has worked very well for me. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. My thing was the night sweats, vaginal dryness, painful intercourse and no interest in sex at all which my husband was not thrilled about. ", "I was having night sweats waking every hour hot flashes etc. no issues giv Did you mean to say this? Hug. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals. Yes, thatwas the only reason why my doctor had me on the Prempro so long was to guard against osteoporosis. a bioidentical HRT. dementia. Maddie6. so when you stop the thearpy you body will start its hormone deficiency symptoms again. Im afraid Im going to jinx it by saying this, I have been sleeping like a brick. These opinions do not represent the opinions of WebMD. I've decided to stop taking Prempro. Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Multivitamins can be trickier: They often contain both water- and fat-soluble vitamins. I am on day for of the Prempro and this stuff is awesome. About 1-2 months into treatment I was feeling better than I had in a long time. This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor. Prempro may increase your risk of developing a condition that may lead to uterine cancer. But ended up gaining 50lbs and also, developed breast cancer at the age of 62. My recovery is still on going but Im healing daily . I have experienced none of the common side effects. I want to go back on it as I felt younger better skin etc. Prempro gives you a false sense of well being while destroying your heart. Have a medical condition, such as cancer, that makes it hard to eat nutritiously. Once-daily antihistamines reach their peak 12 hours . I'm looking at different options. Medically reviewed by Philip Thornton, DipPharm. The American Thyroid Association recommends that levothyroxine be consistently taken 60 minutes before breakfast or at bedtime, at least three hours after dinner.5. The reverse is true when you take a multivitamin on an empty stomach with water your body cant properly absorb the fat-soluble vitamins. And I to get benign cysts on my breast . Customer: Things to remember when you fill your prescription. Take 1 dark red tablet by mouth once daily on days 1 through 14. Your body makes testosterone, progesterone, estrogens, DHEA, cortisol, thyroid hormones, etc., on a 24 hour basis. My night sweats, heart flashes, tiredness, weight gain, energy and depression was unbearable. Progestin reduces the risk of endometrial . A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Shake and flush any remaining contents from the nasogastric or gastric tube into the stomach. My osteoporosis was being monitored by my rheumatologist. Oral estradiol has shorter half life and has to be taken every 12 hours All My Best, Speaking of Women's Health Nurse March 8, 2019 at 9:43am Tweet Stay Connected. Drug class: Sex hormone combinations. The following information includes only the average doses of this medicine. So..I started cutting the tablet (thank heavens it was hard) into two pieces with a pill splitter. The best time to take a multivitamin is with food so any fat can help with absorption. The same side effects are a concern with PEP, but because the treatment only lasts one month, there is less concern about long-term issues. deficiency of anti-clotting agents. Does it work? I will be looking at other options where I might be able to get it through the mail from a different pharmacy. I originally started taking a vitamin pack designed for menopause but the price was a bit outrageous When I saw my doc she suggested taking a low dose (1.5) of Prempro. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. After the first day: 40 mg once a day for up to 14 days. Doctor said it couldn't possibly be the Prempro, but stop taking it if you want to. Shake the syringe right away and leave it for 2 to 3 minutes to thicken. Other than this I have had no other bad side effects; have been on this medicine now for approximately 6 months. Take omeprazole capsules or delayed-release capsules before a meal, preferably in the morning. I am so happy I made this decision because my life is now amazing. In clinical studies of paroxetine for depression, over 20% of people experienced sleepiness, and insomnia occured in over 10%. Hi, I am a 62 year old woman, and after almost 12 years on Prempro, I decided it was time to stop taking it. Post-Menopausal Osteoporosis Prevention (23 reviews), Vaginal Inflammation due to Loss of Hormone Stimulation (5 reviews), Wasting of Tissues of the Vulva (1 reviews), Doctor started me on Prempro 0.625mg/2.5mg ("I start all my patients with this."). Do not chew or crush the pellets. My hot flashes have dwindled to just a slight warmth and I can tell my attitudes a lot different I can see the light again my menopause started in 2014 my last menstrual cycle was June 2017 it has been miserable until yesterday thank you, Started it in my 40s stopped at age 84 one year later got osteoporosis had terrible hot flashes and night sweats now back on doctor warned about blood clots, I started taking Prempro when I was 50. If some of these hormones are too high in the evening, they interfere with the release of night-time hormones. ", "Within days of taking prempro all my symptoms started lifting, barely any hot flashes. I just wondered if anyone else has had this medication work then stop all together? Swallow the capsule and tablet forms of omeprazole whole. As soon as I started this medication, I started feeling less tired and my mood was much better. I have no side affects whatsoever. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, How to Live Life Better With Your Migraine. There are other ways to restore healthy sleep. This is not a pleasant drug to go off as all the synptons u went on it for come back.i have been using it for over 20 years. I waited almost a year and my menstrual cycle never came back but I started having severe hot flashes several times a day and still having seizures and panic attacks. A 2009 randomized crossover study compared the effects of administering levothyroxine in the morning at least one hour before breakfast, within 20 minutes of breakfast, and at bedtime (at least two hours after eating).2 TSH levels were measured in 65 adults with primary hypothyroidism who had been on stable levothyroxine dosages for at least six months. I am 65 yrs. I noticed a difference in 2 days! Drug information provided by: IBM Micromedex. ", "Menopause started at 50. The amount of medicine that you take depends on the strength of the medicine. Take another single PrEP pill 24 hours after your last dose. Your provider can check your levels to see if and where you are deficient, then get you what you need., Cleveland Clinic is a non-profit academic medical center. Just remember that Hormone Replacement Therapy is just that; it replaces the hormones that our body is no longer making on its own. It took about 1 month for all symptoms to go away. I finally broke down and paid my co-pay of $140.00. Take this medicine only as directed by your doctor. We only have one pharmacy in town. I take 1/2 .3 pill every other day. Read and follow these instructions carefully. I have not experienced and side affects at this point. 3 If you have or have had cancer, talk with your healthcare provider about whether you should use PREMPRO or PREMPHASE. The first study on this drug was totally flawed I waved the white flag a month ago and asked my doctor to put me back on it. Some forms of menopause hormone therapy may cause monthly bleeding. See permissionsforcopyrightquestions and/or permission requests. increased risk of blood clotting. Do not crush, break, or chew the capsule or the tablet. Now my pcp wants to put me on anxiety med and I'm not OK with that. My body responded wonderfully to this dosage. I lost my license. And I do feel a little bloated. Have sex - this is the fun bit. I would rather take that small risk than spend the rest of my life not wanting to be alive. By using this Site you agree to the following, By using this Site you agree to the following, light Menopause with no hot flashes but need weight control. I haven't had a period in over 4yrs .